After recently updating to the Windows 10 Build 10586, my Windows Start Menu and Task Bar became unresponsive to mouse clicks. After researching on various forums, most users recommend a fix via the Powershell commands, but it did not work on my PC. However I managed to find a forum comment that recommended a simple fix by using the Command Prompt. This solution worked for me:
Step 1) Run Command Prompt as Administrator.
Step 2) Enter the following command: sfc /scannow
Step 3) Reboot your PC and after rebooting, you should see that the taskbar and start menu is now responding.